Hemorrhagic Fever Viruses

Viruses Causing Hemorrhagic Fever. Safety Laboratory Procedures

Viral hemorrhagic fevers are diseases caused by viruses which belong to different families, many of them causing severe diseases. These viruses may produce different symptomatology together with a severe multisystem syndrome, and the final result might be the production of hemorrhages in several sites of the body. The majority of them have no other treatment than supportive therapy, although so...

Immunosuppression by hemorrhagic fever-causing viruses

The outcomes of human virus infections are tightly linked to cellular immune responses, which are initiated early in the course of the infection by the activation of the innate immune pathways. The typical recognition of viral infections by the innate immune system occurs via the cytoplasmic recognition of viral nucleic acids by cellular receptors, such as the RIG-I-like receptors (RLRs) RIG-I ...

Experience with Ribavirin for Treatment and Postexposure Prophylaxis of Hemorrhagic Fever Viruses: Crimean Congo Hemorrhagic Fever, Lassa Fever, and Hantaviruses

Objectives: The decontamination or physical removal of contaminants from personal protective equipment upon exit from high containment laboratories is crucial to maintain containment and safety of laboratory workers. The current methodology for exiting from high-containment level 4 (CL-4) laboratory calls for laboratory personnel to decontaminate their worn positive pressure suits via “mechanic...

Rodent-Borne Hemorrhagic Fever Viruses: A Special Risk for Mammalogists?

Animal Models of Tick-Borne Hemorrhagic Fever Viruses

Tick-borne hemorrhagic fever viruses (TBHFV) are detected throughout the African and Eurasian continents and are an emerging or re-emerging threat to many nations. Due to the largely sporadic incidences of these severe diseases, information on human cases and research activities in general have been limited. In the past decade, however, novel TBHFVs have emerged and areas of endemicity have exp...